Ceramide-based lipid profiles and the prevalence of type 2 diabetes differ between patients with coronary artery disease and those with peripheral artery disease

Abstract Introduction Serum lipids and metabolic diseases, in particular type 2 diabetes (T2D) non-alcoholic fatty liver disease (NAFLD), predict the atherosclerotic diseases coronary artery (CAD) peripheral arterial (PAD). Purpose The purpose of this study was to investigate how far a more detailed characterization including serum improves discrimination PAD from CAD. Method A cohort 274 statin-naïve patients with either (n=89) or stable CAD (n=185) were referred screening characterized using nuclear magnetic resonance- liquid chromatography-tandem mass spectrometry based advanced lipid lipoprotein analysis. Results validated an independent 1239 We found significant difference T2D prevalence ceramide-based profile between patients. However, neither cholesterol-based markers (including LDL-C, HDL-C) profiles nor LD status differed significantly (figure). remained also after adjusting for body composition, smoking, inflammatory parameters, T2D. Conclusion conclude that differ status, but not other characteristics diseases. Funding Acknowledgement Type funding sources: None.